The Lions, playing on Irish soil for the first time, take on Argentina in the 1888 Cup at the Aviva Stadium on Friday (kick-off 8pm – live on Sky Sports Main Event & TG4).
Saracens and England lock Maro Itoje will captain the side for the very first time as he prepares for his third Tour.
In total 14 players could make their Lions debut against the Pumas, whilst two-times tourists Bundee Aki, Tadhg Beirne, Tom Curry, Marcus Smith, and Duhan van der Merwe all featured in South Africa in 2021.
The Lions can also call on the experience of three-times tourists Elliot Daly and Tadhg Furlong off the bench.
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Lions Head Coach Farrell said: “Congratulations to Maro Itoje ahead of leading out the Lions for the first time – it is a truly special moment and one that very few players ever get to experience.
“Maro has led the group well during our time in Portugal and then Dublin this week. This is also our first opportunity to show what the 2025 Lions are about and what we want to stand for as a team.
“We know that Argentina will challenge us up front and out wide – so Friday night will be a tough contest, but also a great occasion for all the fans.”
British and Irish Lions team to face Argentina:
15. Marcus Smith (Harlequins/ England)
14. Tommy Freeman (Northampton Saints/England)
13. Sione Tuipulotu (Glasgow Warriors/Scotland)
12. Bundee Aki (Connacht Rugby/Ireland)
11. Duhan van der Merwe (Edinburgh Rugby/Scotland)
10. Fin Smith (Northampton Saints/England)
9. Alex Mitchell (Northampton Saints/England)
1. Ellis Genge (Bristol Bears/England)
2. Luke Cowan-Dickie (Sale Sharks/England)
3. Finlay Bealham (Connacht Rugby/Ireland)
4. Maro Itoje (Saracens/England) (capt)
5. Tadhg Beirne (Munster Rugby/Ireland)
6. Tom Curry (Sale Sharks/England)
7. Jac Morgan (Ospreys/Wales)
8. Ben Earl (Saracens/England)
Replacements:
16. Ronan Kelleher (Leinster Rugby/Ireland)
17. Pierre Schoeman (Edinburgh Rugby/Scotland)
18. Tadhg Furlong (Leinster Rugby/Ireland)
19. Scott Cummings (Glasgow Warriors/ Scotland)
20. Henry Pollock (Northampton Saints/England)
21. Tomos Williams (Gloucester Rugby/Wales)
22. Elliot Daly (Saracens/England)
23. Mack Hansen (Connacht Rugby/Ireland)
