LIMERICK City and County Council has granted planning permission for Smiles dental to move into a unit at the Thomas Street centre.
The upper floors of the glass fronted building will be home to mobile taxi application company Uber which is creating 300 jobs in the city.
Meanwhile, Starbucks Coffee has signed up to a unit on the ground floor.
It will be joined by Smiles Dental, which will open its first outlet in the Mid-West region.
The firm applied to the planning authority to change the use of a shop unit to include four dental surgery rooms, an equipment room, a waiting area, a staff canteen and toilets, plus signage.
Smiles will also take over the part of the first floor of the building directly above where it opens.
Limerick City and County Council granted the development, subject to six planning conditions.
These include a stipulation that no awnings, canopies or projecting signs or other signage shall be erected without further planning permission.
The Thomas Street centre, at the junction with Catherine Street, has lain idle for a number of years since it was first constructed at the end of the 2000s.